What exactly is Stevens-Johnson Syndrome?


Stevens-Johnson syndrome (SJS) is actually a rare and disorder that has to have hospitalization. It impacts your skin and mucous membranes which is usually distinguished by using a painful rash that may spread and blister. Usually there are some researchers who believe SJS may be a separate disease from toxic epidermal necrolysis (TEN). However, others believe the 2 main to be the same disease that is available in differing levels. As an example, TEN is also a serious skin ailment that can induce rashes and blistering, but it’s more serious than SJS.

Within the next few paragraphs, we are going to be observing what’s SJS. Additionally, we can discuss SJS in relation to drug unwanted side effects. Needs to be that we are an excellent doctor. Although this article has undergone extensive research to attempt to provide accurate and up-to-date information, do not replace this short article along with your doctor’s advice. Speak to your doctor for those who have inquiries or concerns.

What is Stevens-Johnson Syndrome?

As earlier mentioned, SJS is usually a serious skin disorder the location where the skin becomes painful and trigger rashes, blisters, and/or peeling. Another reputation for it’s Lyell’s syndrome or erythema multiforme major. It could be called something more productive depending on the cause, which include mycoplasma-induced Stevens-Johnson syndrome. By way of example, if it was caused by drug reaction, it really is called drug-induced Stevens-Johnson syndrome.

SJS can be in anyone below the age of 30 years. However, it may problems in seniors too. Additionally, those with a family group good SJS might be quite likely going to provide the condition. Let your doctor know if you or your close relatives experienced SJS.


There are a number of symptoms of SJS, like the following:

  • Flu-like symptoms (fever, coughing, headache, sore mouth and throat)
  • Tiredness
  • Eye irritation
  • Skin pain
  • Red or purple rash
  • Blisters

If your lack of control worsens or persists, call your doctor immediately. If you believe your issue or symptoms seems to be fatal, stop taking all nonessential medications and call 911. Individuals are very likely to experience flu-like symptoms at the outset, which might then be and then rashes or blisters of the epidermis.


Depending on the condition, it might be hard for your physician to distinguish the exact reason behind SJS. Certain drugs or infections can cause the disorder. Since it is an unusual and unpredictable disease, there might ‘t be an identifiable cause the location where the syndrome becomes idiopathic. As a minimum 100 drugs can result in SJS. In a number of cases an allergic reaction to medicines can cause SJS. However, sometimes infections together with vaccinations might cause SJS. Below is a list of more readily available reasons for SJS:


  • Anti-gout medicines (allopurinol)
  • Medications to help treat seizures and mental illness (anticonvulsants and antipsychotics)
  • Medications that really help fight infection (penicillin)
  • Pain relievers (acetaminophen, ibuprofen, naproxen sodium)

Infections along with other Conditions

  • Hepatitis A
  • Herpes virus
  • HIV
  • Pneumonia (specifically in children)
  • Bone marrow transplant
  • Systemic lupus erythematosus
  • Other chronic conditions regarding the joints and connective tissue


SJS is treatable by the healthcare professional. It requires hospitalization and frequently involves treatment inside of a burn center or intensive care unit. The initial thing a medical expert may ask is that you simply stop taking any medications that could be causing your reaction. Additionally, you may be necessary to stop taking all nonessential medications should it be very hard to discern the explanation for your trouble. Other treatment processes may involve supportive care and/or other medications, such as pain medication.

Drugs Related to SJS

Earlier outlined in this article we discussed there are several possible grounds for SJS. Specifically, several cases demonstrate that drugs can lead to SJS. Drug negative effects can range from typical to severe. The most common drugs which might be related to SJS include: allopurinol, anticonvulsants, antipsychotics, acetaminophen, nevirapine, sulfonamides, and certain NSAIDs. A few of these medicine is prescribed to patients with fibromyalgia, HIV/AIDS, lupus, as well as other conditions.

More specifically, listed here is a list of common drugs associated with SJS in terms of other concerns:

  • Acetaminophen: mild to moderate pain (headaches, osteoarthritis, fibromyalgia), fever
  • Allopurinol: kidney stones, gout (some form of arthritis)
  • Anticonvulsants (carbamazepine, lamotrigine, and phenytoin): seizures
  • Antipsychotics: schizophrenia, bpd, fibromyalgia
  • Nevirapine: HIV infection
  • NSAIDs (oxicams): pain, fever, inflammation, anti-thrombosis
  • Sulfonamides: form of antibiotic drugs

There may very well be more corresponding drugs or conditions not listed above. Other elements might also cause or trigger SJS. Ingredient containing hormones . doctor about other possible reasons for SJS. Also, for those who have questions or concerns, find a health care professional you trust.

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